Degree Granting Department
amphiphiles, antimicrobial peptides, biomineralization, calcium carbonate mineralization, Peptidomimetics
Seven novel, amphiphilic AApeptides were prepared. Two cationic, lipo-α-AApeptides, NA-75 and NA-77 were found to possess potent antimicrobial activity against Gram-positive bacteria, with almost no hemolytic activity. In addition to NA-75 and 77, four amphiphilic, γ-AApeptides, NA-133, 135, 137, and 139, and one anionic lipo-α-AApeptide, NA-81, were prepared for molecular self-assembly studies, with several interesting nanostructures observed by TEM. Mineralization of calcium carbonate from gaseous CO2 and Ca2+ in the presence of the 7 AApeptide amphiphiles was also observed by optical microscopy. Several AApeptides were found to be able to influence CaCO3 crystal morphology. Another α-AApeptide, NA-63, was synthesized by a novel, alternative method, which has several potential advantages over the previous synthesis methods.
Scholar Commons Citation
Amin, Mohamad N., "Synthesis of Amphiphilic α- and γ-AApeptides for Antimicrobial, Self-Assembly, and Mineralization Studies" (2013). Graduate Theses and Dissertations.