Graduation Year
2013
Document Type
Thesis
Degree
M.S.
Degree Granting Department
Chemistry
Major Professor
Jianfeng Cai
Keywords
amphiphiles, antimicrobial peptides, biomineralization, calcium carbonate mineralization, Peptidomimetics
Abstract
Seven novel, amphiphilic AApeptides were prepared. Two cationic, lipo-α-AApeptides, NA-75 and NA-77 were found to possess potent antimicrobial activity against Gram-positive bacteria, with almost no hemolytic activity. In addition to NA-75 and 77, four amphiphilic, γ-AApeptides, NA-133, 135, 137, and 139, and one anionic lipo-α-AApeptide, NA-81, were prepared for molecular self-assembly studies, with several interesting nanostructures observed by TEM. Mineralization of calcium carbonate from gaseous CO2 and Ca2+ in the presence of the 7 AApeptide amphiphiles was also observed by optical microscopy. Several AApeptides were found to be able to influence CaCO3 crystal morphology. Another α-AApeptide, NA-63, was synthesized by a novel, alternative method, which has several potential advantages over the previous synthesis methods.
Scholar Commons Citation
Amin, Mohamad N., "Synthesis of Amphiphilic α- and γ-AApeptides for Antimicrobial, Self-Assembly, and Mineralization Studies" (2013). USF Tampa Graduate Theses and Dissertations.
https://digitalcommons.usf.edu/etd/4859
