Graduation Year

2004

Document Type

Thesis

Degree

M.S.B.E.

Degree Granting Department

Biomedical Engineering

Major Professor

Jaroszeski, Mark J.

Keywords

Acetylsalicylic acid, Acetic acid, Surface active drug, Membrane permeability, Salicylic acid, Melanoma cells

Abstract

The purpose of this research was to investigate the effects that aspirin (ASA) and its metabolites, salicylic acid (SA) and acetic acid (AA), have on the delivery of drugs across biological barriers when used in conjunction with electroporation. Electroporation is a technique used to enhance drug delivery across bio-membranes in which a transmembrane potential is induced into cellular membranes, resulting in the creation of aqueous pores that allow molecules to pass through the otherwise impermeable barrier. Aspirin is a widely used drug that has been used for over a century and has been proven relatively safe at normal doses as indicated by the low number of reports of poisoning cases it has been involved in. Components of aspirin are known to soften the cellular membranes by solubilizing the cell's surface proteins.

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