Graduation Year

2008

Document Type

Thesis

Degree

M.S.

Degree Granting Department

Chemistry

Major Professor

Mark L. McLaughlin, Ph.D.

Keywords

Antisense, Antigene, Antibacterial, Antiviral, Cytosine acetic acid

Abstract

Many diseases are caused due to abnormalities in production of specific protein. Across this protein the conventional lock and key mechanism shows binding at the specific cites of protein. However use of antisense technology can prevent formation of protein. It does so by binding to mRNA and prevents transcription. The structural modifications lead to synthetic molecules with 18-mer units which show significant improvement in binding properties, this gives birth to a new class of oligomers called Peptide Nucleic Acid (PNA). We herein report cysteine based PNA called CPNA.

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