Graduation Year
2008
Document Type
Thesis
Degree
M.S.
Degree Granting Department
Chemistry
Major Professor
Mark L. McLaughlin, Ph.D.
Committee Member
Roman Manetsch, Ph.D.
Committee Member
Abdul Malik, Ph.D.
Keywords
Antisense, Antigene, Antibacterial, Antiviral, Cytosine acetic acid
Abstract
Many diseases are caused due to abnormalities in production of specific protein. Across this protein the conventional lock and key mechanism shows binding at the specific cites of protein. However use of antisense technology can prevent formation of protein. It does so by binding to mRNA and prevents transcription. The structural modifications lead to synthetic molecules with 18-mer units which show significant improvement in binding properties, this gives birth to a new class of oligomers called Peptide Nucleic Acid (PNA). We herein report cysteine based PNA called CPNA.
Scholar Commons Citation
Ajmera, Mehul J., "Synthesis of Novel Cysteine Peptide Nucleic Acid (CPNA)" (2007). USF Tampa Graduate Theses and Dissertations.
https://digitalcommons.usf.edu/etd/112
