Title

Radiomics of Lung Nodules: A Multi- Institutional Study of Robustness and Agreement of Quantitative Imaging Features

Document Type

Article

Publication Date

12-2016

Keywords

radiomics, reproducibility, imaging features, lung cancer

Digital Object Identifier (DOI)

http://dx.doi.org/10.18383/j.tom.2016.00235

Abstract

Radiomics is to provide quantitative descriptors of normal and abnormal tissues during classification and prediction tasks in radiology and oncology. Quantitative Imaging Network members are developing radiomic “feature” sets to characterize tumors, in general, the size, shape, texture, intensity, margin, and other aspects of the imaging features of nodules and lesions. Efforts are ongoing for developing an ontology to describe radiomic features for lung nodules, with the main classes consisting of size, local and global shape descriptors, margin, intensity, and texture-based features, which are based on wavelets, Laplacian of Gaussians, Law’s features, gray-level cooccurrence matrices, and run-length features. The purpose of this study is to investigate the sensitivity of quantitative descriptors of pulmonary nodules to segmentations and to illustrate comparisons across different feature types and features computed by different implementations of feature extraction algorithms. We calculated the concordance correlation coefficients of the features as a measure of their stability with the underlying segmentation; 68% of the 830 features in this study had a concordance CC of ≥ 0.75. Pairwise correlation coefficients between pairs of features were used to uncover associations between features, particularly as measured by different participants. A graphical model approach was used to enumerate the number of uncorrelated feature groups at given thresholds of correlation. At a threshold of 0.75 and 0.95, there were 75 and 246 subgroups, respectively, providing a measure for the features’ redundancy.

Comments

Complete list of authors:

Jayashree Kalpathy-Cramer, Artem Mamomov, Binsheng Zhao, Lin Lu, Dmitry Cherezov, Sandy Napel, Sebastian Echegaray, Daniel Rubin, Michael McNitt-Gray, Pechin Lo, Jessica C. Sieren, Johanna Uthoff, Samantha K. N. Dilger, Brandan Driscoll, Ivan Yeung, Lubomir Hadjiiski, Kenny Cha, Yoganand Balagurunathan, Robert Gillies, Dmitry Goldgof

Supplemental Materials

Supplemental Appendix 1

http://dx.doi.org/10.18383/j.tom.2016.00235.sup.01

Supplemental Appendix 2

http://dx.doi.org/10.18383/j.tom.2016.00235.sup.02

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

TOMOGRAPHY, v. 2, issue 4, p. 430-437

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