Comparison of Different Biomaterials for Glaucoma Drainage Devices Part 2
Digital Object Identifier (DOI)
Background Inflammation associated with biomaterials may contribute to the failure of glaucoma drainage devices.
Objective To compare the inflammatory reaction associated with the insertion of Krupin silicone, Molteno polypropylene, and Acrosof end plates in the subconjunctival space of rabbits.
Methods Similar-sized glaucoma end plates made of 3 different biomaterials were sutured to the sclera in the superotemporal quadrant of the rabbit eye. Thirty eyes of 15 albino New Zealand rabbits were randomly assigned to the 3 groups. Conjunctival vascular hyperemia was graded in a masked fashion among the 3 groups. At the end of 3 weeks, the enucleated eyes were examined histologically and by scanning electron microscopy.
Results Molteno polypropylene was associated with more inflammation both in clinical observations and based on histological grading. Silicone and Acrosof were associated with less intense inflammation. One polypropylene end plate was extruded on day 21.
Conclusions Polypropylene appears to be more inflammatory than silicone. Flexible biomaterials appear to be less inflammatory than rigid ones.
Clinical Relevance Bleb failure following glaucoma drainage device implantation could be related to the biomaterial-associated inflammation. Choosing a biomaterial with the least inflammatory potential might enhance the success rate of the glaucoma drainage device.
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Citation / Publisher Attribution
Arch Ophthalmol, v. 118, issue 8, p. 1081-1084
Scholar Commons Citation
Ayyala, Ramesh S.; Michelini-Norris, B; Flores, Anna; Haller, Edward M.; and Margo, Curtis E., "Comparison of Different Biomaterials for Glaucoma Drainage Devices Part 2" (2000). Integrative Biology Faculty and Staff Publications. 293.